These transitions are controlled by key regulatory genes of which the expression shows stepwise patterns, but how the interactions of these genes can determine the multistep processes was unclear. The intermediate stages of the transition provide the biological systems with the opportunities to regulate the transitions in a precise manner. Cell fate transition, or the switch of cellular functions, often involves multiple steps. The functions of cells are dynamically controlled in many biological processes including development, regeneration and disease progression. The network motifs containing a large family of topologies can be useful for analyzing diverse biological systems with multistep transitions. Our findings provide general design principles for multistep cell linage transitions and new insights into the early T cell development. These dynamical features may help to direct the cells to correct lineages during development. These results are in good agreement with experimental observations and they suggest the stable characteristics of the intermediate states in the T cell differentiation. By calculating the energy landscape and minimum action paths for the T cell model, we quantified the stochastic dynamics of the critical factors in response to the differentiation signal with fluctuations. We found that there is an enrichment of these motifs in a transcriptional network controlling the early T cell development, and a mathematical model based on this network recapitulates multistep transitions in the early T cell lineage commitment. With unbiased searching in the network topology space, we found a motif family containing a large set of networks can give rise to four attractors with the stepwise regulations of transcription factors, which limit the reversibility of three consecutive steps of the lineage transition.
Here, we explored gene regulatory circuits that can generate multiple intermediate cellular states with stepwise modulations of transcription factors. However, mechanisms underlying these transitions remain elusive. The multiple intermediate cell lineage states can serve as differentiation checkpoints or branching points for channeling cells to more than one lineages. It does not store any personal data.Multistep cell fate transitions with stepwise changes of transcriptional profiles are common to many developmental, regenerative and pathological processes. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary".
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Take a look at the agenda below and the sessions we have planned for the day. – Transforming and Innovating Public Services Award – Effective Information Sharing and Security Award – Connected Procurement and Commissioning Award – iStandUK Award (for information standards) The event will be held virtually on Thursday 26th May and the Award categories being showcased are: This years showcase will highlight and share project nominations from the Innovation Awards 2021, following on from our Innovation Awards Ceremony on Thursday 19th May 2022.įollowing the success of last year’s showcase, we would again like to invite you to join us in recognising and celebrating the innovative work undertaken within the public sector. The iNetwork Partnership exists to support local public services ‘collaborate to innovate’ and the iNetwork Innovation Awards is an opportunity to highlight, recognise and share leading practice.Įach year we receive dozens of nominations across the iNetwork Innovation Award categories only a handful win, but all are deserving of recognition. Welcome to the iNetwork Innovation Awards Showcase: Celebrate, Learn and Share.
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